The 36-year-old Djokovic, who has only lost twice at Wimbledon in a decade, tops the bill on Monday when he begins the Centre Court programme against Argentina's Pedro Cachin.
Following Djokovic on to the hallowed turf, five-times women's champion Venus Williams, aged 43, will try and roll back the years as her 24th Wimbledon appearance begins against Ukraine's Elina Svitolina.
Rain showers are expected throughout the opening days although that will not impact those with tickets for Centre Court and Court One, both of which boast retractable roofs.
Political slogans of any sort are banned around the grounds with Wimbledon organisers determined the focus should remain firmly on the tennis.
All 17 players from those two countries, including men's third seed Daniil Medvedev, are competing as neutrals.
Persons:
Serbia's Novak Djokovic, Hannah Mckay LONDON, Novak Djokovic, Roger Federer, Rafa Nadal, Serena Williams, Nick Kyrgios, Djokovic, Federer, Bjorn Borg's, Argentina's Pedro Cachin, Venus Williams, Ukraine's Elina Svitolina, Williams, Iga, Swiatek, China's Zhu Lin, Suncream, Putin's, Daniil Medvedev, Martyn Herman, Ed Osmond
Organizations:
Lawn Tennis, Croquet Club, Wimbledon REUTERS, Wimbledon, Court, Thomson
Locations:
London, Britain, England, Serbian, Russia, Belarus, Ukraine, Russian